选择性雌激素受体调节剂
三苯氧胺
乳腺癌
雌激素受体
医学
雌激素
肿瘤科
雌激素受体
2019年冠状病毒病(COVID-19)
癌症研究
癌症
生物信息学
疾病
内科学
生物
传染病(医学专业)
作者
Shuying Hu,Feiying Yin,Litao Nie,Xueying Wang,Jian Qin,Jian Chen
标识
DOI:10.3389/fendo.2022.829879
摘要
Owing to the ongoing coronavirus disease 2019 (COVID-19) pandemic, we need to pay a particular focus on the impact of coronavirus infection on breast cancer patients. Approximately 70% of breast cancer patients express estrogen receptor (ER), and intervention therapy for ER has been the primary treatment strategy to prevent the development and metastasis of breast cancer. Recent studies have suggested that selective estrogen receptor modulators (SERMs) are a potential therapeutic strategy for COVID-19. With its anti-ER and anti-viral combined functions, SERMs may be an effective treatment for COVID-19 in patients with breast cancer. In this review, we explore the latent effect of SERMs, especially tamoxifen, and the mechanism between ER and virus susceptibility.
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