谷胱甘肽
癌细胞
细胞内
化学
酶
过氧化氢
纳米医学
细胞生物学
生物化学
生物物理学
纳米颗粒
材料科学
生物
癌症
纳米技术
遗传学
作者
Ling Chang,Hui Huang,Wei Feng,Hao Fu,Fenggang Qi,Jianjun Li,Yu Chen
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:14 (16): 6171-6183
被引量:6
摘要
The satisfactory therapeutic effects of chemodynamic therapy (CDT) dependent solely on endogenous hydrogen peroxide (H2O2) from tumor cells are difficult to achieve. This is closely attributed to the high metabolic activity of malignant cancer cells, prompting the rapid self-protection and proliferation. Here, we report a programmed self-assembly multilayered nanostructure, thioglycolic acid (TGA)-Cu coordination nanoparticles with rapid GSH-response characteristics, for intensifying the CDT efficiency and comprehensively inhibiting the tumor metabolic activity via exchanging the TGA ligand with glutathione (GSH) in the tumor cell. In the formulation, TGA, a small toxic molecule, was combined with Cu ions and securely delivered to the destination for inactivating the functional protein by depriving their spatial structure, then inducing the inhibition of metabolism and meiosis. Simultaneously, the oxidative stress that originated from the oxidized glutathione (GSSG)-Cu complex triggering H2O2 compels the cancer cells to perform active and passive death processes in concert with the inhibition of intracellular enzyme activities. Thus, this work is not only expected to be a heuristic strategy for amplifying the therapeutic effect of CDT together with the inhibition of enzyme activity, but also may advance the construction of stimulus-response bio-functional materials.
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