无容量
易普利姆玛
医学
内科学
联合疗法
肿瘤科
肝细胞癌
贝伐单抗
实体瘤疗效评价标准
癌症
胃肠病学
外科
临床研究阶段
免疫疗法
临床试验
化疗
作者
Daniel Roessler,Osman Öcal,Alexander Philipp,Daniel Markwardt,S Munker,Julia Mayerle,Leonie S. Jochheim,Katharina Hammer,Christian M. Lange,Andreas Geier,Max Seidensticker,Florian P. Reiter,Enrico N. De Toni,Najib Ben Khaled
标识
DOI:10.1007/s00432-022-04206-8
摘要
Abstract Introduction Immune checkpoint inhibitor (ICI)-based regimens are transforming the landscape of hepatocellular carcinoma (HCC) treatment. We describe the effect of combined ipilimumab and nivolumab in patients with advanced HCC after the failure of prior ICI-based combination treatments. Methods The clinical course of patients with advanced HCC who received combined ipilimumab and nivolumab after prior ICI-based combination therapies was assessed. Progression-free survival (PFS), overall response rate (ORR) and disease control rate (DCR) per RECIST v1.1 and mRECIST, overall survival (OS), and safety were analyzed. Results Of 109 patients treated with atezolizumab and bevacizumab or other ICI-based combination treatments, ten patients received subsequent therapy with ipilimumab and nivolumab. The majority of patients had Barcelona Clinic Liver Cancer (BCLC) Stage C (80%) HCC and a preserved liver function as defined by Child–Pugh A (80%). At a median follow-up of 15.3 months, ORR for ipilimumab and nivolumab was 30% with a DCR of 40%. Median PFS was 2.9 months and the median OS was 7.4 months. Conclusion This retrospective study demonstrates that combined ipilimumab and nivolumab can be effective and tolerable after prior ICI-based combination therapies and provides a rationale for the prospective clinical evaluation of this treatment sequencing.
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