可药性
神经氨酸酶
病毒
计算生物学
甲型流感病毒
核糖核酸
RNA聚合酶
生物
病毒学
药物发现
化学
遗传学
生物信息学
基因
作者
Michele Tonelli,Elena Cichero
标识
DOI:10.2174/0929867323666160210124930
摘要
In this review we discuss drug design strategies directed to the development of potential anti-influenza A(H1N1) inhibitors of M2 ion channel, neuraminidase (NA), hemagglutinin (HA) and RNA-dependent RNA-polymerase complex (RdRp) major targets, following temporal chronology of their findings. Besides searching for new chemotypes, eventually active against new targets of influenza A (H1N1), the design of optimized analogues of proven drugs is largely pursued, taking into account the emerging insight into the mechanisms of resistance to existing antivirals. Computational studies are also summarized, in order to highlight the structural requirements for further chemical optimizations. Keywords: Influenza A(H1N1) virus, drug design, M2 ion channel blockers, HA inhibitors, NA inhibitors, RNA polymerse complex inhibitors.
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