Age-Related Toxicity of Trastuzumab

The use of adjuvant trastuzumab has dramatically changed the natural history of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. The adverse-effect profile of trastuzumab, including cardiac toxicity, has been well defined, thanks to several well-designed international clinical trials involving thousands of patients with long-term follow-up. However, we do not have sufficient data to understand the toxicity of trastuzumab in …