Model for Dynamic Study of Deep Venous Thrombosis in Rats

Objective To establish a model of deep venous thrombosis(DVT)in rats for dynamic study of antithrombotics or thrombolysis on thrombosis.Methods SD rats(n=60)were randomly divided into thrombosis model group(n=36),control group(n=18)and sham operation group(n=6).An improved method was used to make the inferior caval vein ligated in SD rats of thrombosis model group.After operation,rats in thrombosis model group and control group were divided into 6 period groups.The changes of thrombus and internal surface of vessels in each period were observed in thrombosis model group and were compared with those in other two groups,respectively.Results Stable venous thrombus were observed in all inferior caval vein in thrombosis model group,and the proximal part of venous thrombus was unobstructed and consistent with the pathological change of venous thrombosis during acute stage in human body.Conclusion The DVT model in rats was successfully established,which maybe helpful for dynamic study of the effect of antithrombotics or thrombolysis on thrombosis.