The Effect of Quercetin on Proliferation and Apoptosis of HO-8910 Ovarian Cancer Cell

Objective To study the effect of quercetin on proliferation and apoptosis of HO-8910 ovarian cancer cell in vitro.Methods The proliferation of cells was detected by MTT method.Cell cycle and apoptotic percentage were analyzed by flow Cytometry(FCM).The expression of p53 and Bcl-2 were analyzed by FCM.Results Quercetin could inhibit the proliferation of HO-8910 cell as direct relation of concentrations and times.The flow cytometry showed that the proportion of G1 phase and the apoptotic rate were increased significantly in quercetin groups,the proportion of S phase and G2/M phase was reduced.In the FCM quercetin induced upregulation expression of p53 and downregulation expression of Bcl-2.Conclusions Quercetin could inhibit growth and induce apoptosis of ovarian cancer HO-8910 cell.Cell cycle was controlled in G1/G0.Meanwhile,quercetin could induce upregulation expression of p53 and downregulation expression of Bcl-2,while may be the mechanism of apoptosis of ovarian cancer by quercetin.