血管生成
细胞生物学
内皮干细胞
人脐静脉内皮细胞
信号转导
脐静脉
细胞生长
生物
细胞
化学
体外
癌症研究
生物化学
作者
Maria Teresa Gentile,Olga Pastorino,Maurizio Bifulco,Luca Colucci-D’Amato
摘要
Angiogenesis is a phenomenon that includes different processes, such as endothelial cell proliferation, differentiation, and migration, that lead to the formation of new blood vessels and involve several signal transduction pathways. Here we show that the tube formation assay is a simple in vitro method to evaluate the impact of natural products on angiogenesis and to investigate the molecular mechanisms involved. In particular, in the presence of the water extract of Ruta graveolens (RGWE), endothelial cells are no longer able to form a cell-cell network and that the RGWE effects on human umbilical vein endothelial cell (HUVEC) tube formation is abolished by the constitutive activation of MEK.
科研通智能强力驱动
Strongly Powered by AbleSci AI