生物高聚物
壳聚糖
逐层
图层(电子)
透明质酸
化学工程
纳米颗粒
抗菌活性
化学
超分子化学
纳米技术
材料科学
细菌
有机化学
聚合物
分子
工程类
生物
遗传学
作者
António Francesko,Kristina Ivanova,Javier Hoyo,Sílvia Pérez‐Rafael,Petya Petkova,Margarida M. Fernandes,Thomas Heinze,Ernest Mendoza,Tzanko Tzanov
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2018-07-27
卷期号:19 (9): 3628-3636
被引量:27
标识
DOI:10.1021/acs.biomac.8b00626
摘要
In this study, freestanding nanobiocomposite films were obtained by the sequential deposition of biopolymer-capped silver nanoparticles (AgNPs) and hyaluronic acid (HA). At first, dispersions of AgNPs decorated with chitosan (CS) or aminocellulose (AC) were synthesized by applying high intensity ultrasound. These polycationic nanoentities were layer-by-layer assembled with the HA polyanion to generate stable 3D supramolecular constructs, where the biopolymer-capped AgNPs play the dual role of active agent and structural element. SEM images of the assemblies revealed gradual increase of thickness with the number of deposited bilayers. The composites of ≥50 bilayers were safe to human cells and demonstrated 100% antibacterial activity against Staphylococcus aureus and Escherichia coli. Moreover, the films containing CSAgNPs brought about the total prevention of biofilm formation reducing the cells surface adherence by up to 6 logs. Such nanobiocomposites could serve as an effective barrier to control bacterial growth on injured skin, burns, and chronic wounds.
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