再生医学
间充质干细胞
旁分泌信号
牙髓干细胞
干细胞
细胞疗法
医学
干细胞疗法
再生(生物学)
组织工程
血管生成
神经发生
生物信息学
神经科学
生物
病理
细胞生物学
生物医学工程
癌症研究
内科学
受体
作者
Charlène Kichenbrand,Émilie Velot,Patrick Menu,Vanessa Moby
出处
期刊:Tissue Engineering Part B-reviews
[Mary Ann Liebert]
日期:2019-02-01
卷期号:25 (1): 78-88
被引量:76
标识
DOI:10.1089/ten.teb.2018.0168
摘要
Mesenchymal stem cells (MSC) have a lot of potential in regenerative medicine, and MSC-based therapies are currently explored in numerous research fields. Among these cells, deciduous or permanent dental pulp-MSC represent a promising option in tissue engineering. This expectation is based on their capacity to self-renew, to repair various damaged tissues and organs due to their multipotency, as well as their ability to modulate immune system. They present other advantages such as the harvesting by a simple, painless, and noninvasive procedure and the absence of ethical considerations. The role played by these cells in the reparative process is mainly attributed to paracrine mechanisms mediated by their secreted factors, namely the secretome. The secreted factors can be found in the cell culture medium, called conditioned medium (CM). Moreover, CM presents many advantages compared with cells such as possible use in allogeneic therapies. This minireview aims at investigating the therapeutic use of dental pulp MSC-derived CM to develop cell-free therapies. The analysis of the available literature illustrates its massive panel of potential applications: mainly reduction of inflammation, promotion of angiogenesis and neurogenesis, reduction of stroke or ischemia, and organ regeneration. Furthermore, studies often highlight its superiority over the other sources of CM derived from other stem cells for the same applications. Dental pulp MSC-derived CM is an attractive, noninvasive, and acellular tool for therapeutic approaches in regenerative medicine. This promising novel approach should be further explored for clinical applications.
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