Ho3+/Pr3+ co-doped AlF3 -based glass fibers were fabricated by using a rod-in-tube method based on the matrix glass composition of AlF3−BaF2−CaF2−YF3−SrF2−MgF2−LiF−ZrF4−PbF2 . Under the pump of a 1150 mW Raman fiber laser, a 2.9 µm laser was observed in a 19 cm long Ho3+/Pr3+ co-doped AlF3 -based glass fiber with an output power of 173 mW and a slope efficiency of 10.4%. Ho3+/Pr3+ co-doped AlF3 -based glasses were fabricated to investigate the deactivation effects of Pr3+ ions on the Ho3+:5I7 level. Our results showed that the Ho3+/Pr3+ co-doped AlF3 -based glass fibers are potential gain media for ∼2.9µm lasers.