血脑屏障
脑转移
转移
并行传输
癌症
癌细胞
医学
脑癌
跨细胞
癌症研究
癌症干细胞
神经科学
生物
病理
内科学
中枢神经系统
遗传学
细胞生物学
膜
磁导率
作者
Jawad Fares,Deepak Kanojia,Aida Rashidi,Ilya V. Ulasov,Maciej S. Lesniak
标识
DOI:10.1016/j.trecan.2020.04.007
摘要
Brain metastasis is an important cause of mortality in patients with cancer and represents the majority of all intracranial tumors. A key step during the metastatic journey of the cancer cell to the brain is the invasion through the blood–brain barrier (BBB). Nevertheless, the molecular mechanisms that govern this process remain unknown. The BBB has been blamed for limiting the access of therapeutic drugs to the brain, which provides a safe haven for cancer cells in the brain and confers poor prognosis for the patient. Here, we explore the genes that control the transmigration of metastatic cancer cells across the BBB, offering new targets for the development of gene and cell therapies against brain metastases.
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