杜皮鲁玛
医学
美波利祖马布
鼻息肉
奥马佐单抗
慢性鼻-鼻窦炎
生活质量(医疗保健)
临床试验
内科学
疾病
安慰剂
鼻窦炎
重症监护医学
皮肤病科
外科
免疫球蛋白E
免疫学
哮喘
病理
替代医学
抗体
嗜酸性粒细胞
护理部
作者
Claus Bachert,Nan Zhang,Carlo Cavaliere,Wang Wen,Elien Gevaert,Olga Krysko
标识
DOI:10.1016/j.jaci.2020.01.020
摘要
With the increasing recognition of the role of type 2 immune responses in chronic rhinosinusitis, its severity, recurrence, and comorbidities, several biologics targeting IL-4, IL-5, and IL-13 as well as IgE have been administered in small proof-of-concept studies. Recently, the first phase 3 trials have been reported with dupilumab, an IL-4 receptor antagonist, demonstrating a significant and clinically relevant reduction of the disease burden from polyp size and sinus involvement to symptoms and smell; these changes consecutively led to an important increase in quality of life. Finally, the biologic versus placebo treatment reduced the need for systemic glucocorticosteroids and sinus surgery significantly and clinically meaningfully. Dupilumab today is registered for the treatment of chronic rhinosinusitis with nasal polyps in Europe and the United States. Within a year, 2 further phase 3 trials with omalizumab and mepolizumab will be reported. With this development, without any doubt, a new era for the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps has begun. Questions on the indication of the biologics, the selection of patients, and finally criteria for monitoring the efficacy in individual patients need to be urgently answered, and care pathways need to be established integrating the current standard of care including surgery.
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