医学
代谢综合征
肥胖
前瞻性队列研究
内科学
队列
人口
队列研究
脂肪肝
入射(几何)
人体测量学
体质指数
疾病
环境卫生
物理
光学
作者
Simona Bo,Giovanni Musso,Guglielmo Beccuti,M. Fadda,D. Fedele,Roberto Gambino,Luigi Gentile,Marilena Durazzo,Ezio Ghigo,Maurizio Cassader
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2014-09-24
卷期号:9 (9): e108467-e108467
被引量:114
标识
DOI:10.1371/journal.pone.0108467
摘要
Background/Objectives It has been hypothesized that assuming most of the caloric intake later in the day leads to metabolic disadvantages, but few studies are available on this topic. Aim of our study was to prospectively examine whether eating more of the daily caloric intake at dinner leads to an increased risk of obesity, hyperglycemia, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). Subjects/Methods 1245 non-obese, non-diabetic middle-aged adults from a population-based cohort underwent a 3-day food record questionnaire at enrollment. Anthropometric values, blood pressure, blood metabolic variables, and estimated liver fat were measured at baseline and at 6-year follow-up. Design Prospective cohort study. Results Subjects were divided according to tertiles of percent daily caloric intake at dinner. A significant increase in the incidence rate of obesity (from 4.7 to 11.4%), metabolic syndrome (from 11.1 to 16.1%), and estimated NAFLD (from 16.5 to 23.8%) was observed from the lower to higher tertile. In a multiple logistic regression model adjusted for multiple covariates, subjects in the highest tertile showed an increased risk of developing obesity (OR = 2.33; 95% CI 1.17–4.65; p = 0.02), metabolic syndrome (OR = 1.52; 95% CI 1.01–2.30; p = 0.04), and NAFLD (OR = 1.56; 95% CI 1.10–2.22; p = 0.01). Conclusions Consuming more of the daily energy intake at dinner is associated with an increased risk of obesity, metabolic syndrome, and NAFLD.
科研通智能强力驱动
Strongly Powered by AbleSci AI