表观遗传学
组蛋白
组蛋白脱乙酰基酶
乙酰化
组蛋白脱乙酰基酶2
组蛋白脱乙酰基酶5
染色质
神经发生的表观遗传调控
染色质重塑
HDAC11型
组蛋白甲基转移酶
HDAC4型
组蛋白乙酰转移酶
神经科学
生物
组蛋白密码
遗传学
核小体
基因
作者
Johannes Gräff,Li‐Huei Tsai
摘要
Long-lasting memories require specific gene expression programmes that are, in part, orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in cognitive processes, histone acetylation has spurred considerable interest. Whereas increments in histone acetylation have consistently been shown to favour learning and memory, a lack thereof has been causally implicated in cognitive impairments in neurodevelopmental disorders, neurodegeneration and ageing. As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.
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