γ-氨基丁酸受体
免疫系统
安定
免疫学
受体
生物
甲型流感病毒
蛋白质亚单位
CD8型
细胞
病毒
内科学
医学
药理学
基因
生物化学
作者
Robert D. Sanders,Vinod K. Grover,John Goulding,Alexandra Godlee,Stefan Gurney,Robert J. Snelgrove,Daqing Ma,Suveer Singh,Mervyn Maze,Tracy Hussell
标识
DOI:10.1016/j.jneuroim.2015.04.001
摘要
Benzodiazepines increase vulnerability to infection through α1 subunit dependent Υ-amino-butyric-type-A (GABAA) signalling. Immune cell expression of GABAA receptors and the effect of diazepam on influenza infection was investigated. In patients with pneumonia, α1 GABAA subunits were expressed on alveolar macrophages and blood monocytes. In mice, influenza induced dynamic changes in immune cell GABAA subunit expression: α1 subunits decreased on alveolar macrophage, but increased on monocytes, CD4+ and CD8+ T cells. Following influenza viral infection, diazepam delayed weight loss on day 3 but later increased weight loss. Viral load was unaffected but increased bacterial superinfection was noted on day 10.
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