代谢物
肾
内科学
体内
内分泌学
维生素D与神经学
新陈代谢
化学
维生素
体外
肾切除术
生物
医学
生物化学
生物技术
作者
Richard W. Gray,I. Boyle,Hector F. DeLuca
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1971-06-18
卷期号:172 (3989): 1232-1234
被引量:286
标识
DOI:10.1126/science.172.3989.1232
摘要
The appearance of a polar metabolite of 25-hydroxychotecalciferol has been studied in the intestinal mucosas of nephrectomized rats and rats which have been made uremic by ureter ligation. In confirmation of previous work by Fraser and Kodicek, it was found that nephrectomy prevents the appearance of this metabolite in the intestine. On the other hand, equivalent amounts of the metabolite were found in uremic rats and in sham-operated controls, showing that the production of this metabolite is independent of the uremic state of the animals. In addition, it was shown that the metabolite produced in vitro by kidney homogenates is identical to that found in vivo in the intestine.
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