自催化
同手性
对映体过量
化学
对映选择合成
对映体
手性(物理)
催化作用
分子
产量(工程)
小分子
计算化学
立体化学
有机化学
热力学
手征对称破缺
物理
生物化学
量子力学
夸克
Nambu–Jona Lasinio模型
作者
Kenso Soai,Takanori Shibata,Hiroshi Morioka,Kaori Choji
出处
期刊:Nature
[Springer Nature]
日期:1995-12-01
卷期号:378 (6559): 767-768
被引量:956
摘要
THE homochirality of natural amino acids and sugars remains a puzzle for theories of the chemical origin of life1–18. In 1953 Frank7 proposed a reaction scheme by which a combination of autocatalysis and inhibition in a system of replicating chiral molecules can allow small random fluctuations in an initially racemic mixture to tip the balance to yield almost exclusively one enantiomer. Here we show experimentally that autocatalysis in a chemical reaction can indeed enhance a small initial enantiomeric excess of a chiral molecule. When a 5-pyrimidyl alkanol with a small (2%) enantiomeric excess is treated with diisopropylzinc and pyrimidine-5-car-boxaldehyde, it undergoes an autocatalytic reaction to generate more of the alkanol. Because the reaction involves a chiral catalyst generated from the initial alkanol, and because the catalytic step is enantioselective, the enantiomeric excess of the product is enhanced. This process provides a mechanism by which a small initial imbalance in chirality can become overwhelming.
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