Clinical and biological features of acute promyelocytic leukemia patients developing retinoic acid syndrome during induction treatment with all-trans retinoic acid and idarubicin

hemoglobin level were not significant predictors of ACS events. The rate of pain was not increased in those with asthma diagnosis (0.72 events per patient year for those with asthma and 0.60 events per patient year for those without asthma, p value=0.53). Furthermore, baseline white blood cell count, percent fetal hemoglobin and baseline hemoglobin were not significant predictors of pain episodes (Table When compared to the remaining group of children without asthma (n=280), children taking daily inhaled corticosteroids (n=17) had an increased rate of ACS (0.43 events per patient-year vs. 0.16 events per patient-year; p-value=0.002) and no significant increase in rate of pain (0.99 events per patientyear vs. 0.59 events per patient-year; p=0.122) .