糖原合酶
蛋白激酶B
磷酸烯醇丙酮酸羧激酶
胰岛素受体
葡萄糖转运蛋白
碳水化合物代谢
糖异生
胰岛素受体底物
糖原
葛兰素史克-3
化学
PI3K/AKT/mTOR通路
三氟化锡
生物化学
内科学
IRS1
过剩4
内分泌学
信号转导
葡萄糖摄取
胰岛素
新陈代谢
生物
酶
胰岛素抵抗
医学
标识
DOI:10.1016/j.jff.2021.104793
摘要
In this study, (-)epicatechin (EC) and β-glucan (BG) were identified as the active compounds in highland barley grain that modulated glucose metabolism. The mechanism underlying EC may target on insulin receptor and regulate target on insulin receptor substrate-1 /phosphatidylinositol 3-kinase / protein kinase B (Akt) pathway, and BG may target on mammalian rapamycin receptor and regulate the Akt pathway. EC and BG showed anti-hyperglycemic effects and modulated hepatic glucose metabolism in mice with impaired glucose tolerance. Moreover, EC combined with BG showed synergistic effects on the Akt pathway, thereby improved glucose uptake through up-regulating glucose transporter 4, improved glycogen synthesis by down-regulating glycogen synthase kinase-3β, and inhibiting gluconeogenesis by down-regulating phosphoenolpyruvate carboxykinase 1 protein expression. These results provide evidence of a whole highland barley grain diet to prevent type 2 diabetes or developing EC and BG as new dietary supplement.
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