皮诺森布林
体内
肝细胞
药理学
化学
蜂胶
体外
活性氧
炎症
生物
抗氧化剂
免疫学
生物化学
食品科学
生物技术
类黄酮
作者
Pan Cao,Qian Chen,Chunxia Shi,Maohua Pei,Gaofeng Wang,Zuo-Jiong Gong
标识
DOI:10.1016/j.ejphar.2021.174610
摘要
Acute liver failure (ALF) is a life-threatening disease and affects multiple organ systems. Pro-inflammatory factors derived from macrophage plays a key role in septicemia. Pinocembrin is a natural favonoid compound, which can be extracted from honey, propolis and several other plants. Recent investigations demonstrate that Pinocembrin has a variety of pharmacological activities, including anti-inflammatory and antioxidant. To investigate the effects of Pinocembrin on ALF, we explored its possible molecular mechanisms through the experiments in vivo and in vitro. Pre-treatment with Pinocembrin attenuated LPS-induced hepatocyte dysfunction and reduced levels of pro-inflammatory factors and macrophages infiltration. Pinocembrin inhibited the hepatocyte apoptosis and pro-inflammatory reaction of peritoneal macrophages by reducing reactive oxygen species (ROS) via the Sirt1/PPARα signaling pathway. Our study suggests that Pinocembrin might represent a novel therapeutic drug and offers a new method for the treatment of ALF.
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