Issue Information

Front cover: Confocal image of a 5-day culture of amacrine and photoreceptors obtained from newborn rat retinas treated with pigment epithelium-derived factor (PEDF) for 3 days. Image Content: A photo of the cells fixed and stained with anti-acetylated tubulin (green) and TOPRO-3 (red) is shown. PEDF stimulated extensive amacrine axonal outgrowth and protected photoreceptors from cell death, simultaneously promoting their differentiation. Read the full article ‘Pigment epithelium-derived factor (PEDF) and derived peptides promote survival and differentiation of photoreceptors and induce neurite-outgrowth in amacrine neurons’ by G. Michelis, O. L. German, R. Villasmil, T. Soto, N. P. Rotstein, L. Politi and S. P. Becerra (J. Neurochem. 2021, vol. 159 (5), pp. 840–856) on doi:10.1111/jnc.15454