神经科学
代谢型谷氨酸受体5
星形胶质细胞
突触发生
代谢型谷氨酸受体
突触可塑性
谷氨酸受体
生物
变质塑性
体感系统
神经可塑性
神经病理性疼痛
中枢神经系统
受体
生物化学
作者
Yosuke Danjo,Eiji Shigetomi,Yukiho Hirayama,Kenji Kono,Tatsuya Ishikawa,Yugo Fukazawa,Keisuke Shibata,Kenta Takanashi,Bijay Parajuli,Youichi Shinozaki,Sun Kwang Kim,Junichi Nabekura,Schuichi Koizumi
摘要
Activation of astrocytes has a profound effect on brain plasticity and is critical for the pathophysiology of several neurological disorders including neuropathic pain. Here, we show that metabotropic glutamate receptor 5 (mGluR5), which reemerges in astrocytes in a restricted time frame, is essential for these functions. Although mGluR5 is absent in healthy adult astrocytes, it transiently reemerges in astrocytes of the somatosensory cortex (S1). During a limited spatiotemporal time frame, astrocytic mGluR5 drives Ca2+ signals; upregulates multiple synaptogenic molecules such as Thrombospondin-1, Glypican-4, and Hevin; causes excess excitatory synaptogenesis; and produces persistent alteration of S1 neuronal activity, leading to mechanical allodynia. All of these events were abolished by the astrocyte-specific deletion of mGluR5. Astrocytes dynamically control synaptic plasticity by turning on and off a single molecule, mGluR5, which defines subsequent persistent brain functions, especially under pathological conditions.
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