烟酰胺单核苷酸
安慰剂
匹兹堡睡眠质量指数
医学
物理疗法
握力
随机对照试验
生活质量(医疗保健)
睡眠剥夺
睡眠质量
内科学
失眠症
精神科
护理部
酶
化学
替代医学
病理
烟酰胺腺嘌呤二核苷酸
昼夜节律
NAD+激酶
生物化学
作者
Mijin Kim,Jaehoon Seol,Toshiya Sato,Yuichiro Fukamizu,Takanobu Sakurai,Tomohiro Okura
出处
期刊:Nutrients
[MDPI AG]
日期:2022-02-11
卷期号:14 (4): 755-755
被引量:24
摘要
Deteriorating sleep quality and physical or mental fatigue in older adults leads to decreased quality of life and increased mortality rates. This study investigated the effects of the time-dependent intake of nicotinamide mononucleotide (NMN) on sleep quality, fatigue, and physical performance in older adults. This randomized, double-blind placebo-controlled study evaluated 108 participants divided into four groups (NMN_AM; antemeridian, NMN_PM; post meridian, Placebo_AM, Placebo_PM). NMN (250 mg) or placebo was administered once a day for 12 weeks. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index. Fatigue was evaluated using the "Jikaku-sho shirabe" questionnaire. Grip strength, 5-times sit-to-stand (5-STS), timed up and go, and 5-m habitual walk were evaluated to assess the physical performance. Significant interactions were observed between 5-STS and drowsiness. 5-STS of all groups on post-intervention and drowsiness of the NMN_PM and Placebo_PM groups on mid- and post-intervention showed significant improvement compared with those in pre-intervention. The NMN_PM group demonstrated the largest effect size for 5-STS (d = 0.72) and drowsiness (d = 0.64). Overall, NMN intake in the afternoon effectively improved lower limb function and reduced drowsiness in older adults. These findings suggest the potential of NMN in preventing loss of physical performance and improving fatigue in older adults.
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