[The predictive value of serum alkaline phosphatase combined with parathyroid hormone in all-cause and cardiovascular mortality in maintenance hemodialysis patients].

To analyze the predictive value of serum intact parathyroid hormone (iPTH) and alkaline phosphatase (ALP) on all-cause and cardiovascular mortality in maintaining hemodialysis (MHD) patients. A total of 224 MHD patients were prospectively investigated and followed up for 2 years. Serum iPTH levels were not associated with all-cause death and cardiovascular death (HR=1.001, 95%CI 1.000-1.004, P=0.048) . The level of serum ALP was associated with cardiovascular death (HR=1.002, 95%CI 1.000-1.004, P=0.033) . ALP≥106 IU/L was an independent risk factor for cardiovascular death in MHD patients (P<0.05) . The joint variable was correlated with mortality in MHD patients (HR=1.002, 95%CI 1.000~1.004, P=0.033) , that equal or over 37.28 was an independent risk factor for mortality (P<0.05).探讨联合检测血清碱性磷酸酶（ALP）和全段甲状旁腺激素（iPTH）水平对维持性血液透析（MHD）患者全因和心血管事件死亡风险的预测价值。入选MHD患者224例，检测患者血清iPTH、ALP等临床指标，随访2年，采用Cox回归分析全因死亡和心血管死亡的危险因素。结果显示，ALP水平与患者心血管事件死亡相关（HR=1.001, 95%CI 1.000~1.004, P=0.048)，ALP≥106 IU/L是患者心血管事件死亡的独立危险因素（P<0.05）。联合检测ALP、iPTH与全因死亡相关（HR=1.002, 95%CI 1.000~1.004, P=0.033)，若联合检测ALP-iPTH≥37.28是MHD患者全因死亡的独立危险因素（P<0.05）。血清iPTH水平与MHD患者全因死亡和心血管事件死亡无显著关系。.