量子产额
荧光
光化学
光动力疗法
材料科学
吸光度
摩尔吸收率
荧光寿命成像显微镜
纳米颗粒
接受者
聚合物
纳米技术
化学
分析化学(期刊)
光学
有机化学
色谱法
物理
凝聚态物理
复合材料
作者
Baoling Li,Ting Xu,Xiaosha Wang,Shaojing Zhao,Benhua Wang,Lihui Jiang,Xiangzhi Song,Minhuan Lan
标识
DOI:10.1142/s1793545822400065
摘要
Near infrared (NIR) fluorescence imaging guided photodynamic therapy (PDT) is a technique which has been developed in many clinical trials due to its advantage of real-time optical monitoring, specific spatiotemporal selectivity, and minimal invasiveness. For this, photosensitizers with NIR fluorescence emission and high 1 O 2 generation quantum yield are highly desirable. Herein, we designed and synthesized a “donor–acceptor” (D-A) structured semiconductor polymer (SP), which was then wrapped with an amphiphilic compound (Pluronic[Formula: see text] F127) to prepare water-soluble nanoparticles (F-SP NPs). The obtained F-SP NPs exhibit good water solubility, excellent particle size stability, strong absorbance at deep red region, and strong NIR fluorescent emission characteristics. The maximal mass extinction coefficient and fluorescence quantum yield of these F-SPs were calculated to be 21.7 L/(g[Formula: see text]cm) and 6.5%, respectively. Moreover, the 1 O 2 quantum yield of 89% for F-SP NPs has been achieved under 635 nm laser irradiation, which is higher than Methylene Blue, Ce6, and PpIX. The outstanding properties of these F-SP NPs originate from their unique D-A molecular characteristic. This work should help guide the design of novel semiconductor polymer for NIR fluorescent imaging guided PDT applications.
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