自愈水凝胶
自愈
材料科学
细胞包封
纳米技术
机械强度
伤口愈合
组织工程
药物输送
生物医学工程
复合材料
医学
高分子化学
外科
病理
替代医学
作者
Anupama Devi V. K.,Rohin Shyam,Arunkumar Palaniappan,Amit Jaiswal,Tae-Hwan Oh,A. Joseph Nathanael
出处
期刊:Polymers
[MDPI AG]
日期:2021-10-31
卷期号:13 (21): 3782-3782
被引量:45
标识
DOI:10.3390/polym13213782
摘要
Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ''smart self-healing hydrogels'' which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel's mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.
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