Graphene‐Paper‐Based Electrodes on Plastic and Textile Supports as New Platforms for Amperometric Biosensing

Abstract The possibility of exfoliating graphite into graphene sheets allows the researchers to produce a material, termed “graphene paper” (G‐paper), conductive as graphite but more flexible and processable. G‐paper is already used for electronic applications, like conductors, antennas, and heaters, outperforming metal conductors thanks to its high flexibility, lightness, chemical stability, and compatibility with polymeric substrates. Here, the effectiveness in the use of G‐paper for the realization of electrodes on flexible plastic substrates and textiles, and their applicability as amperometric sensors are demonstrated. The performance of these devices is compared with commercial platforms made of carbon‐based inks, finding that they outperform commercial devices in sensing nicotinamide adenine dinucleotide (NADH), a key molecule for enzymatic biosensing; the electrodes can achieve state‐of‐the‐art sensitivity (107.2 μA m m −1 cm −2 ) and limit of detection (0.6 × 10 −6 m ) with no need of additional functionalization. Thanks to this property, the stable deposition of a suitable enzyme, namely lactate dehydrogenase, on the electrode surface is used as a proof of concept of the applicability of this new platform for the realization of a biosensor. The possibility of having a single material suitable for antennas, electronics, and now sensing opens new opportunities for smart fabrics in wearable electronic applications.