加巴能
神经科学
医学
γ-氨基丁酸受体
补品(生理学)
内科学
睡眠剥夺
抑制性突触后电位
荷包牡丹碱
内分泌学
清醒
γ-氨基丁酸
癫痫
睡眠(系统调用)
海马体
作者
Sai Surthi Konduru,Yu-Zhen Pan,Eli Wallace,Jesse A. Pfammatter,Mathew V. Jones,Rama Maganti
标识
DOI:10.1101/2021.03.06.434210
摘要
Abstract Patients with epilepsy report that sleep deprivation is a common trigger for breakthrough seizures. The basic mechanism of this phenomenon is unknown. In the Kv1.1-/- mouse model of epilepsy, daily sleep deprivation indeed exacerbated seizures though these effects were lost after the 3rd day. Sleep deprivation also accelerated mortality in ~52% of Kv1.1-/- mice, not observed in controls. Voltage-clamp experiments on the day after recovery from sleep deprivation showed reductions in GABAergic tonic inhibition in dentate granule cells both in Kv1.1-/- and wild-type mice. Our results suggest that sleep deprivation is detrimental to seizures and survival, possibly due to reductions in GABAergic tonic inhibition.
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