怀孕
自身抗体
医学
抗磷脂综合征
心磷脂
磷脂酸
子痫前期
抗体
子痫
肌醇
免疫学
产科
内科学
化学
磷脂
生物化学
生物
受体
膜
遗传学
作者
L Hradecký,I Šubrt,Z Ulčová-Gallová
标识
DOI:10.1111/j.1600-0897.2009.00759.x
摘要
Problem The present work was undertaken to investigate the occurence of autoantibodies to eight various phospholipids in time of urgent termination of the pregnancy (sectio caesarea) in patients in reproductive age with severe preeclamptic symptoms. Method of study Autoantibodies against annexin V, ph‐serine, ph‐ethanolamine, ph‐inositol, ph‐DL‐glycerol, cardiolipin, beta2‐glycoprotein I (beta2‐GPI), and phosphatidic acid were studied by ELISA methods. Results Increased levels of IgA‐beta2‐glycoprotein I, IgG‐beta2‐glycoprotein I, IgG‐ anti‐ph‐serine, and IgG‐anticardiolipin were found in sera of preeclamptic women in the time of urgent sectio caesarea when compared to the control group with physiological pregnancy. Conclusion Supposed increase in various antiphospholipid antibodies (aPLs) levels due to the stress during the short time of admission and a need for a quick medical decision to terminate the pregnancy was not unambiguously proven, but our results are evidently influenced by the current urgent life‐saving treatment.
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