活性氧
炎症
肝细胞
肝细胞癌
化学
细胞凋亡
细胞质
细胞生物学
癌症研究
氧化应激
生物化学
生物
免疫学
体外
作者
Koji Miyanishi,Shingo Tanaka,Hiroki Sakamoto,Junji Kato
标识
DOI:10.1016/j.freeradbiomed.2018.07.006
摘要
Iron is an essential for organisms and the liver plays a major role in its storage. In pathologic conditions, where iron absorption from the intestine or iron uptake into the hepatocytes is increased, excess iron accumulates in the hepatocytes, leading to hepatocyte injury through the production of free radicals. Iron exerts its toxicity by catalyzing the generation of reactive oxygen species (ROS). ROS causes cell injury by inducing damage to the lysosomal, cytoplasmic, nuclear and mitochondrial membranes, apoptosis through activation of the caspase cascade, and hyperoxidation of fatty chains. In this manuscript, we reviewed the articles regarding role of iron in hepatic inflammation and hepatocellular carcinoma.
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