Recent Development in N-Auxilixary-Assisted Intramolecular Amination for Amine Substrates

Direct coupling of N–H with C–H has aroused great attention in the last decades; during which the directing-group-assisted intramolecular C–N bond formation via transition metal has been achieved significant progress. Herein, we highlight the recent development in the directing-group-assisted intramolecular amination for amine substrates to build the important N-containing heterocyclic compounds. 1 Introduction 2 Triflamide-Promoted Intramolecular Amination 3 Picolinamide-Assisted Intramolecular Amination 4 Palladium-Catalyzed Intramolecular Amination under Assistance of Oxalyl Amide 5 Conclusion