蛋白酵素
蛋白酶
生物
生物技术
重组DNA
计算生物学
生物化学
酶
基因
作者
Jonathan Tremblay,Marie‐Claire Goulet,Dominique Michaud
出处
期刊:Biochimie
[Elsevier]
日期:2019-11-01
卷期号:166: 184-193
被引量:18
标识
DOI:10.1016/j.biochi.2019.06.006
摘要
Dozens of studies have assessed the practical value of plant cystatins as ectopic inhibitors of Cys proteases in biological systems. The potential of these proteins in crop protection to control herbivorous pests and pathogens has been documented extensively over the past 25 years. Their usefulness to regulate endogenous Cys proteases in planta has also been considered recently, notably to implement novel traits of agronomic relevance in crops or to generate protease activity-depleted environments in plants or plant cells used as bioreactors for recombinant proteins. After a brief update on the basic structural characteristics of plant cystatins, we summarize recent advances on the use of these proteins in plant biotechnology. Attention is also paid to the molecular improvement of their structural properties for the improvement of their protease inhibitory effects or the fine-tuning of their biological target range.
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