蛋白酶
蛋白酵素
计算生物学
蛋白质组学
生物
生物标志物发现
化学生物学
生物化学
酶
基因
作者
Matej Vizovišek,Robert Vidmar,Marcin Dra̧g,Marko Fonović,Guy S. Salvesen,Boris Turk
标识
DOI:10.1016/j.tibs.2018.07.003
摘要
Proteases are considered of major importance in biomedical research because of their crucial roles in health and disease. Their ability to hydrolyze their protein and peptide substrates at single or multiple sites, depending on their specificity, makes them unique among the enzymes. Understanding protease specificity is therefore crucial to understand their biology as well as to develop tools and drugs. Recent advancements in the fields of proteomics and chemical biology have improved our understanding of protease biology through extensive specificity profiling and identification of physiological protease substrates. There are growing efforts to transfer this knowledge into clinical modalities, but their success is often limited because of overlapping protease features, protease redundancy, and chemical tools lacking specificity. Herein, we discuss the current trends and challenges in protease research and how to exploit the growing information on protease specificities for understanding protease biology, as well as for development of selective substrates, cleavable linkers, and activity-based probes and for biomarker discovery.
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