Use of Adjuvant Radiotherapy in the Treatment of High-risk Cutaneous Squamous Cell Carcinoma With Perineural Invasion

in the setting of additional high-risk features and should be considered.Limitations of this study include its retrospective design, cohort size, treatment bias, and potential referral bias, with our findings suggesting the need for prospective, multicenter controlled trials.Our data suggest favorable outcomes of cSCC with perineural invasion treated with surgery and adjuvant radiotherapy, highlighting the potential role of adjuvant radiotherapy for patients with large-caliber perineural invasion and those with small-caliber perineural invasion in the presence of other high-risk features.