调节器
炎症
免疫学
髓样
功能(生物学)
髓系细胞
生物
受体
医学
细胞生物学
内科学
遗传学
基因
作者
Grzegorz Krzak,Cory M. Willis,JA Smith,Stefano Pluchino,Luca Peruzzotti‐Jametti
标识
DOI:10.1016/j.it.2020.11.004
摘要
The rapidly evolving area of immunometabolism has shed new light on the fundamental properties of products and intermediates of cellular metabolism (metabolites), highlighting their key signaling roles in cell-to-cell communication. Recent evidence identifies the succinate–succinate receptor 1 (SUCNR1) axis as an essential regulator of tissue homeostasis. Succinate signaling via SUCNR1 guides divergent responses in immune cells, which are tissue and context dependent. Herein, we explore the main cellular pathways regulated by the succinate–SUCNR1 axis and focus on the biology of SUCNR1 and its roles influencing the function of myeloid cells. Hence, we identify new therapeutic targets and putative therapeutic approaches aimed at resolving detrimental myeloid cell responses in tissues, including those occurring in the persistently inflamed central nervous system (CNS).
科研通智能强力驱动
Strongly Powered by AbleSci AI