医学
子宫肌瘤
高强度聚焦超声
超声波
放射科
强度(物理)
妇科
量子力学
物理
作者
Shahram Vaezy,Victor Y. Fujimoto,Christie L. Walker,Roy W. Martin,Y. Emil,Lawrence A. Crum
标识
DOI:10.1067/mob.2000.105347
摘要
Objective: The purpose of this study was to investigate the potential efficacy of high-intensity focused ultrasound for the treatment of uterine fibroid tumors in a nude mouse model. Study Design: A total of 60 female athymic nude mice were inoculated subcutaneously with 3 to 5 × 106 ELT-3 cells, a uterine fibroid tumor cell line. Tumor size was monitored with transcutaneous caliper measurements. The high-intensity focused ultrasound probe was a concave, single-element, high-power transducer that operated at a frequency of 3.5 MHz. The tumors were treated for 30 to 60 seconds using a high-intensity focused ultrasonic intensity of 2000 W/cm2, depending on the tumor size. Results: A single high-intensity focused ultrasonic treatment resulted in an average reduction in tumor volume of 91% within 1 month of the treatment. Histologic analysis of tumors treated with high-intensity focused ultrasound showed coagulation necrosis and nuclear fragmentation of tumor cells. Conclusion: High-intensity focused ultrasound effectively reduced uterine fibroid tumor size in a nude mouse model. Further studies are needed to assess the in situ response of uterine fibroids to high-intensity focused ultrasonic treatment. (Am J Obstet Gynecol 2000;183:6-11.)
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