Isolation of malonyl oleanolic acid hemiester as anti-HIV protease substance from the stems of Cynomorium songaricum

OBJECTIVE Further investigation on the bio active constituents of the stems of Cynomorium songaricum .METHODS The compounds were isolated with chromatographic technology, including HPLC. Their structures were determined by spectroscopic methods.RESULTS Malonyl oleanolic acid hemiester (Ⅰ) and zingerone 4 O β D glucopyranoside (Ⅱ) were isolated from the plant.CONCLUSION Both compounds were isolated from this plant family for the first time and compound Ⅰ potently inhibited the activity of HIV protease.