The Relationship between CYP1A1 Genetic Polymorphism and Susceptibility to Lung Cancer

To explore the effects of combined CYP1A1 Msp1 genotypes with Ile/Val genotypes on susceptibility to lung cancer. Msp1 and Ile/Val genotypes of CYP1A1 gene were detected with the methods of PCR RFLP and allele specific amplification(ASA) in a case control study,including 92 cases of lung cancer and 98 hospital controls. Msp1 polymorphism site:The risk of lung cancer with the individuals of genotype B or genotype C was 1 85 times greater than that with the individual of genotype A ( χ 2=4 36,P0 05,OR=1 85,95% CI 1 04～3 30 ).Ile/Val polymorphism site:The risk of lung cancer of the individuals with genotype Val/Val was 3 3 times greater than the individual with genotype Ile/Ile ( χ 2=4 12,P0 05,OR=3 3,95% CI 1 02～10 72 ).The lung cancer risks of individuals with combined Ile/Ile genotype and A genotype were compared with these of individuals combined Ile/Val genotype and B ( χ 2=5 81,P0 05,95% CI 1 7～9 96 ),the individuals combined Ile/Val genotype and C genotype ( χ 2=4 74,P0 05,95% CI 1 11～20 9 ) and the individuals combined Val/Val genotype and C genotype ( χ 2=4 42,P0 05,95% CI 1 27～23 6 ). [Conclusion] The genotype C and genotype Val/Val of CYP1A1 gene may be susceptible to lung cancer,the individuals with two susceptible genotypes were more susceptible to lung cancer.