光热治疗
介孔二氧化硅
纳米复合材料
药物输送
纳米棒
材料科学
纳米技术
纳米医学
纳米颗粒
表面改性
磁共振成像
介孔材料
生物医学工程
化学
医学
放射科
有机化学
物理化学
催化作用
作者
H. T. Feng,Yutao Zhao,Yeping Li,Xueyong Qi,Song Shen,Shengwang Zhou
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2023-07-17
卷期号:6 (14): 13001-13012
被引量:1
标识
DOI:10.1021/acsanm.3c01722
摘要
Nanotechnology provides the platform to develop functional nanocomposites with outstanding features, such as persistent luminescence (PL), photothermal conversion, magnetic resonance (MR), and so on, that has been incorporated in nanomedicine for diagnosis and therapy. Herein, the nanocomposites of ZnGa2O4:Cr3+ embedded in mesoporous silica coating surrounding gold nanorods (cGNR@MSNs) were developed for the codelivery of chemotherapeutic drugs and anti-CD40 antibodies. The nanocomposites were functionalized with tetrazaheterocycle linking divinylpyrimidine derivatives (DOTVs), which covalently capture anti-CD40 by disulfide re-bridging on the surface of cGNR@MSNs. The anti-CD40-mediated dual drug delivery system simultaneously realized the combination of chemo-, immuno-, and photothermal therapies, enhancing the synergistic effect of combination therapy for multiple tumor cells. Moreover, the nanodrug delivery system achieved multimodality imaging with fluorescence, PL, and MR modes for precise diagnosis. This study provides fascinating insights into the development of nanocomposite-based multimodality imaging strategies and imaging-guided combination therapies.
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