DNA折纸
膜
纳米技术
DNA纳米技术
小泡
DNA
合成生物学
生物物理学
脂质双层
千分尺
材料科学
化学
纳米结构
生物
工程类
生物信息学
生物化学
机械工程
作者
Juanjuan Yang,Kevin Jahnke,Ling Xin,Xinxin Jing,Pengfei Zhan,Andreas Peil,Alessandra Griffo,Marko Škugor,Donglei Yang,Sisi Fan,Kerstin Göpfrich,Hao Yan,Pengfei Wang,Na Liu
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-07-13
卷期号:23 (14): 6330-6336
被引量:1
标识
DOI:10.1021/acs.nanolett.3c00750
摘要
Membrane morphology and its dynamic adaptation regulate many cellular functions, which are often mediated by membrane proteins. Advances in DNA nanotechnology have enabled the realization of various protein-inspired structures and functions with precise control at the nanometer level, suggesting a viable tool to artificially engineer membrane morphology. In this work, we demonstrate a DNA origami cross (DOC) structure that can be anchored onto giant unilamellar vesicles (GUVs) and subsequently polymerized into micrometer-scale reconfigurable one-dimensional (1D) chains or two-dimensional (2D) lattices. Such DNA origami-based networks can be switched between left-handed (LH) and right-handed (RH) conformations by DNA fuels and exhibit potent efficacy in remodeling the membrane curvatures of GUVs. This work sheds light on designing hierarchically assembled dynamic DNA systems for the programmable modulation of synthetic cells for useful applications.
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