神经科学
默认模式网络
重性抑郁障碍
扁桃形结构
壳核
心理学
功能磁共振成像
医学
作者
Peter Zhukovsky,Maria Ironside,Jessica M. Duda,Amelia D. Moser,Kaylee E. Null,Maëva Dhaynaut,Marc D. Normandin,Nicolas J. Guehl,Georges El Fakhri,Madeline Alexander,Laura M. Holsen,Miriam A. Bredella,Rajesh Narendran,Jocelyn Hoye,Evan D. Morris,Shiba M. Esfand,Jill M. Goldstein,Diego A. Pizzagalli
标识
DOI:10.1016/j.biopsych.2024.02.005
摘要
Abstract
Background
Understanding the neurobiological effects of stress is critical for addressing the etiology of major depressive disorder (MDD). Using a dimensional approach involving individuals with differing degree of MDD risk, we investigated (1) the effects of acute stress on cortico-cortical and subcortical-cortical functional connectivity (FC), and (2) how such effects related to gene expression and receptor maps. Methods
Across 115 participants (37 controls, 39 remitted MDD, 39 current MDD), we evaluated the effects of stress on FC during the Montreal Imaging Stress Task. Using partial least squares regression, we investigated genes whose expression in the Allen Human Brain Atlas was associated with the anatomical patterns of stress-related FC change. Finally, we correlated stress-related FC change maps with opioid and GABA-A receptor distribution maps derived from positron emission tomography. Results
Results revealed robust effects of stress on global cortical connectivity, with increased global FC in frontoparietal and attentional networks and decreased global FC in the medial default mode network. Moreover, robust increases emerged in FC of the caudate, putamen and amygdala with regions from the ventral attention/salience network, frontoparietal network and motor networks. Such regions showed preferential expression of genes involved in cell-to-cell signaling (OPRM1, OPRK1, SST, GABRA3, GABRA5), similar to previous genetic MDD studies. Conclusions
Acute stress altered global cortical connectivity and increased striatal connectivity with cortical regions that express genes previously associated with imaging abnormalities in MDD and are rich in μ− and κ− opioid receptors. These findings point to overlapping circuitry underling stress response, reward, and MDD.
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