Absorption-based colorimetric detection of nickel(II) ion by phase separation of thermoresponsive magnetic nanoparticles under microflow

Therma-Max™ LSA Streptavidin is a thermoresponsive magnetic nanoparticle (TMNP). It can be introduced conveniently to molecular recognition groups by avidin-biotin interaction. In this study, we demonstrated the detection of nickel(II) ions by the magnetic separation of TMNP induced by their phase transition under microflow. The NTA-tagged TMNP solution mixed with a Ni