串扰
重编程
转分化
肿瘤微环境
癌相关成纤维细胞
转录因子
转移
癌症研究
生物
血管生成
肿瘤进展
上皮-间质转换
癌细胞
癌症
细胞
细胞生物学
生物信息学
干细胞
遗传学
基因
肿瘤细胞
物理
光学
作者
Xiaoyan Zhang,Meng Zhang,Hongbin Sun,Wenrong Xu,Xin Wang,Weiqi Sheng,Ming Xu
标识
DOI:10.1016/j.jare.2024.01.033
摘要
Transcription factors (TFs) fulfill a critical role in the formation and maintenance of different cell types during the developmental process as well as disease. It is believed that cancer-associated fibroblasts (CAFs) are activation status of tissue-resident fibroblasts or derived from form other cell types via transdifferentiation or dedifferentiation. Despite a subgroup of CAFs exhibit anti-cancer effects, most of them are reported to exert effects on tumor progression, further indicating their heterogeneous origin. of review This review aimed to summarize and review the roles of TFs in the reciprocal crosstalk between CAFs and tumor cells, discuss the emerging mechanisms, and their roles in cell-fate decision, cellular reprogramming and advancing our understanding of the gene regulatory networks over the period of cancer initiation and progression. This manuscript delves into the key contributory factors of TFs that are involved in activating CAFs and maintaining their unique states. Additionally, it explores how TFs play a pivotal and multifaceted role in the reciprocal crosstalk between CAFs and tumor cells. This includes their involvement in processes such as epithelial-mesenchymal transition (EMT), proliferation, invasion, and metastasis, as well as metabolic reprogramming. TFs also have a role in constructing an immunosuppressive microenvironment, inducing resistance to radiation and chemotherapy, facilitating angiogenesis, and even 'educating' CAFs to support the malignancies of tumor cells. Furthermore, this manuscript delves into the current status of TF-targeted therapy and considers the future directions of TFs in conjunction with anti-CAFs therapies to address the challenges in clinical cancer treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI