Emotional experiences in male and female participants with schizophrenia spectrum disorders and healthy controls: an experience sampling method study

Schizophrenia spectrum disorders (SSD) are associated with disturbances in emotional experience, but sex differences and comparisons to healthy controls (HC) remain poorly explored. This exploratory study used Experience Sampling Method (ESM) to examine emotional variability, instability and daily/hourly patterns of positive and negative emotions across sexes in SSD and HC. A total of 103 SSD participants (47.9%) were compared to 112 HC (52.1%), matched for sex and age. Data on sociodemographics, clinical status, functioning and quality of life were collected. ESM assessed emotional experiences over one week. For positive emotions, HC males reported higher levels on weekdays and morning-to-midday hours, whereas no sex differences emerged in SSD. Males with SSD showed greater weekly variability in positive emotions than HC males, while no significant differences were found among females. For negative emotions, females with SSD exhibited greater daily variability than female HC, with no significant sex differences within HC or SSD. Regarding emotional instability, female HC displayed higher instability than HC males, while no significant sex differences emerged in SSD. This study shows significant sex differences in emotional experiences among SSD and HC, with different sex patterns in SSD. Targeted, sex-specific interventions are crucial for improving emotional regulation and treatment outcomes in SSD.Trial registration: ISRCTN.org identifier: ISRCTN21141466.