脂肪肝
疾病
脂质代谢
小RNA
长非编码RNA
编码(社会科学)
核糖核酸
基因
酒精性肝病
医学
细胞凋亡
生物信息学
生物
计算生物学
病理
遗传学
肝硬化
内科学
统计
数学
作者
Lianrui Cao,Na Qu,Xin Wang,Lijiang Chen,Mingxia Liu
标识
DOI:10.1016/j.clinre.2023.102095
摘要
Non-alcoholic fatty liver disease is a disease that is currently prevalent in the world, increasingly becoming the mainstay of liver diseases. And its prevalence is rapidly increasing, but its pathogenesis is not entirely understood. Long non-coding RNAs have increasingly gained attention as science has progressed in recent years. Studies have shown that long non-coding RNAs are involved in a variety of biological processes in vivo, such as proliferation, differentiation, and apoptosis, and can affect disease by regulating gene expression. This review explores the biological processes involving long non-coding RNAs, including lipid metabolism, glucose metabolism, liver fibrosis, and apoptosis. In addition, we summarize how the different long non-coding RNAs involved in each process function. Finally, the shortcomings of long non-coding RNAs as potential therapeutic targets are briefly described. In conclusion, this article provides a clear visualization of the link that exists between long non-coding RNAs and non-alcoholic fatty liver disease.
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