化学
级联
产量(工程)
辐照
组合化学
立体化学
磷酸化
反应条件
光催化
药物化学
光化学
有机化学
催化作用
色谱法
生物化学
物理
核物理学
冶金
材料科学
作者
Fanlin Zeng,Zhi-Yang Zhang,Pengcheng Yin,Fu-Kun Cheng,Xiao-Lan Chen,Lingbo Qu,Zhong‐Yan Cao,Bing Yu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-10-21
卷期号:24 (43): 7912-7917
被引量:9
标识
DOI:10.1021/acs.orglett.2c02930
摘要
3-(2-(Ethynyl)phenyl)quinazolinones were designed and synthesized as a class of novel and efficient skeletons for phosphorylation/cyclization reactions. Under visible light irradiation, a series of phosphorylated quinolino[2,1-b]quinazolinones (35 examples, up to 87% yield) were first synthesized from 3-(2-(ethynyl)phenyl)quinazolinones and diarylphosphine oxides by using 4CzIPN as a photocatalyst under mild conditions. This reaction was also applicable under sunlight irradiation. Moreover, the reaction efficiency could be significantly improved under continuous-flow conditions.
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