神经科学
神经降压素
能量稳态
光遗传学
暴饮暴食
扁桃形结构
生物
下丘脑
人口
肥胖
内分泌学
医学
内科学
神经肽
环境卫生
受体
作者
Alessandro Furlan,Alberto Corona,Sara Boyle,Radhashree Sharma,Rachel Rubino,Jill Habel,Eva Gablenz,Jacqueline Giovanniello,Semir Beyaz,Tobias Janowitz,Stephen D. Shea,Bo Li
标识
DOI:10.1038/s41593-022-01178-3
摘要
Obesity is a global pandemic that is causally linked to many life-threatening diseases. Apart from some rare genetic conditions, the biological drivers of overeating and reduced activity are unclear. Here, we show that neurotensin-expressing neurons in the mouse interstitial nucleus of the posterior limb of the anterior commissure (IPAC), a nucleus of the central extended amygdala, encode dietary preference for unhealthy energy-dense foods. Optogenetic activation of IPACNts neurons promotes obesogenic behaviors, such as hedonic eating, and modulates food preference. Conversely, acute inhibition of IPACNts neurons reduces feeding and decreases hedonic eating. Chronic inactivation of IPACNts neurons recapitulates these effects, reduces preference for sweet, non-caloric tastants and, furthermore, enhances locomotion and energy expenditure; as a result, mice display long-term weight loss and improved metabolic health and are protected from obesity. Thus, the activity of a single neuronal population bidirectionally regulates energy homeostasis. Our findings could lead to new therapeutic strategies to prevent and treat obesity.
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