异源的
吲哚试验
生物合成
异源表达
计算生物学
代谢工程
合成生物学
生物
化学
生物化学
基因
重组DNA
作者
Taro Ozaki,Atsushi Minami,Hideaki Oikawa
摘要
Covering: 2013 to 2022In this review, we provide an overview elucidating the biosynthetic pathway and heterologous production of fungal indole diterpenes (IDTs). Based on the studies of six IDT biosynthesis, we extracted nature's strategy: (1) two-stage synthesis for the core scaffold and platform intermediates, and (2) late-stage modifications for installing an additional cyclic system on the indole ring. Herein, we describe reconstitution studies applying this strategy to the synthesis of highly elaborated IDTs. We also discuss its potential for future biosynthetic engineering.
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