佐剂
抗原
增强剂
肽
抗原呈递
免疫系统
抗原处理
蛋白质亚单位
主要组织相容性复合体
化学
免疫学
MHC I级
医学
生物化学
T细胞
基因
作者
Shuyu Jin,Shao-Hua Zhuo,Yasushi Takemoto,Yan-Mei Li,Motonari Uesugi
摘要
The effective co-delivery of antigens and immune potentiators (adjuvants) and the high degree of antigen presentation have been two major challenges in the development of subunit vaccines. Here, we address these issues by conjugating peptide antigens with cholicamide, a self-assembling small molecule adjuvant. Co-assemblies of the conjugates and cholicamide achieved high levels of both cytokine induction and MHC class II peptide presentation.
科研通智能强力驱动
Strongly Powered by AbleSci AI